Zhejiang University broke out，2021年已经在SNC 发表17篇论文（转...

大师大楼 · 发表于 2021-8-24 17:39:53

Zhejiang University broke out!17 articles on Nature, Science, and Cell have been published in 2021
2021-08-24 17:25:42 HKT

Since 2021 (as of August 12, 2021), the research team with Zhejiang University as the communication unit has published 17 research results in Cell, Nature and Science, and has made significant progress in the fields of physics, materials science, and life sciences. .

[1] Chemical reactions are often conceptualized as the conversion of individual molecules into products, but they are usually observed in experiments that explore the overall average behavior. The single-molecule approach goes beyond the overall average and reveals the statistical distribution of reaction locations, pathways, and kinetics. This has been achieved by modern optical methods using optical traps and scanning probe microscopes to manipulate and observe individual responses at specific locations with high spatial resolution and the use of ultra-sensitive photodetectors, which enable high-throughput single-molecule measurements. However, effective detection of single-molecule solution chemistry is still challenging.

On August 11, 2021, Jiandong Feng's team from Zhejiang University published a research paper entitled "Direct imaging of single-molecule electrochemical reactions in solution" in Nature. Use in super-resolution microscopy. This method utilizes a chemiluminescence reaction involving a ruthenium complex produced electrochemically on the electrode, ensuring minimal background signal. This allows the research to directly capture the electrochemiluminescence single photon of a single reaction and develop a super-resolution electrochemiluminescence microscope to image the adhesion dynamics of living cells with high temporal and spatial resolution. The research predicts that the method will advance the basic understanding of electrochemical reactions and prove useful for bioassay and cell imaging applications.

[2] On July 16, 2021, Wang Jun from Nanjing University of Technology, Xing Huabin from Zhejiang University and Yan Ning from National University of Singapore published a research paper entitled " Self-assembled iron-containing mordenite monolith for carbon dioxide sieving " on Science Online . , the study of a simple, template-free hydrothermal process for self-assembly heteroatom zeolite monolith Fe-MOR (n) (where n is the initial Fe / Si molar ratio), its inherent high mechanical strength can be It can be used directly as a shaped physical adsorbent. In CO2 capture, the Fe-MOR(n) series screens CO2, Ar, N2 and CH4 based on molecular size, and exhibits unprecedented CO2 absorption and CO2/Ar(N2, CH4) selectivity and fast adsorption kinetics. In short, Fe-MOR zeolite monoliths with ultra-high mechanical strength are self-assembled using a binder-free and template-free hydrothermal route, which is cost-effective, energy-saving and environmentally friendly. Some isolated tetrahedral Fe elements are located in one-dimensional microporous channels, resulting in a precise narrowing of the zeolite pore system of the microchannels. The combination of skeleton iron element and this pore feature gives high CO2 adsorption capacity, effective size-based molecular screening ability and excellent water stable separation performance. This material has low energy consumption when separating CO2/N2 (CH4), and has high product recovery and purity. All these characteristics make Fe-MOR monoliths a promising self-forming adsorbent. This work demonstrates a high-performance self-forming adsorbent for CO2 capture and highlights the practical application potential of heteroatom zeolite materials in gas adsorption and separation.

[3] On July 8, 2021, Guangming Tao from Huazhong University of Science and Technology and Yaoguang Ma from Zhejiang University published a research paper entitled " Hierarchical-morphology metafabric for scalable passive daytime radiative cooling " in Science Online . This research has developed a breakthrough An optical metafabric with a Hierarchical-morphology structure that can be prepared in large quantities and has excellent daytime radiant cooling capacity, which is of great significance to the realization of efficient outdoor personal thermal management.

[4] In the early morning of July 8, 2021, the team of Professor Tong Limin of Zhejiang University published a research paper entitled " Elastic ice microfibers " in Science Online . The research reported on this magical ice-the most elastic and resilient ice ever. Microfiber . This ice microfiber can be bent into an almost complete circle like cooked noodles, and then restored to its original shape . Moreover, in addition to excellent elasticity and flexibility, the ice microfiber can also transmit light along its length like the most advanced on-chip light guide, and is expected to be used in low-loss optical waveguides operating at low temperatures.

[5] On June 25, 2021, Tang Ruikang and Liu Zhaoming of Zhejiang University jointly published a research paper entitled " Pressure-driven fusion of amorphous particles into integrated monoliths " in Science Online. The particles are fused together with pressure to produce an inorganic monolith of amorphous calcium carbonate. Due to its structural continuity, the monolith is transparent and its mechanical strength is close to that of single crystal calcite. The dynamic water channel in the amorphous body is cooperatively controlled by the water content and the applied pressure, and promotes the mass transfer of particle fusion. This research strategy provides an alternative to traditional sintering methods, which should be attractive for building temperature-sensitive biominerals and biomaterials as a whole structure.

[6] The oxide interface between LaAlO3 and KTaO3 (111) can have a superconducting state. On May 14, 2021, Xie Yanwu of Zhejiang University, Sun Jirong and Zhou Yi from the Institute of Physics of the Chinese Academy of Sciences (co-first authors are Chen Zheng and Liu Yuan of Zhejiang University and Zhang Hui of Beijing University of Aeronautics and Astronautics) published on Science Online titled " Electric field control of superconductivity at the LaAlO3/KTaO3(111) interface " research paper, this research applies a gate voltage (VG) across KTaO3 to continuously adjust the interface from superconductivity to an insulating state to produce a dome Tc-VG dependence of the shape, where Tc is the transition temperature. Electrical gating has a small effect on carrier density, but has a large effect on mobility. This study explains the adjustment of mobility based on the change in the spatial distribution of the carriers in the interface, thereby explaining the effective disorder. As the temperature decreases, the resistance on both sides of the superconductor and the insulation is saturated at the lowest temperature, which indicates that there is a quantum metal state related to the failed superconductor and/or fragile insulator. This discovery presents a new perspective for people to explore low-temperature quantum phenomena, and also provides new ideas for the research and development of superconducting devices .

[7] The coupling of electron spin and orbital degrees of freedom is one of the most profound effects in crystals and is the basis of various strange phenomena. However, as a basic particle, electrons also carry another basic physical quantity, namely spin. How to manipulate the spin and develop electronic devices with faster speed and lower energy consumption have been the goals pursued by the scientific and engineering fields since the 1990s. On May 5, 2021, Zheng Yi, Xu Zhuan of Zhejiang University, and Xia Qinglin of Central South University published a research paper entitled " Rashba valleys and quantum Hall states in few-layer black arsenic " in Nature . The strong spin-orbit coupling effect of continuous and reversible regulation of the external electric field is found in the dimensional electronic state, which realizes the high-speed and precise control of the spin; at the same time, in the new spin-energy valley coupling Rashba physical phenomenon, a novelty is found Quantum Hall state. This research will provide a solid foundation for the development of high-efficiency and low-energy spintronic devices, and will have a positive significance for further deepening the understanding of the quantum Hall phenomenon, as well as the research of quantum computing relying on topological superconducting devices.

[8] On April 28, 2021, Professor Liu Jianfeng from Huazhong University of Science and Technology, Zhang Yan from Zhejiang University and Jean-Philippe Pin from Montpellier University published a joint newsletter titled " Structural basis of GABAB receptor-Gi protein coupling " on Nature . The research paper reported on the structure of the C-type heterodimer GABA B receptor, which is activated by the inhibitory transmitter GABA and exists as an active form complexed with the Gi1 protein. The study found that a single G protein interacts with the GB2 subunit of the GABA B receptor at a site that mainly involves intracellular loop 2 on one side of the transmembrane domain. This is in contrast to the G protein binding in the central chamber observed in other types of GPCRs. This binding mode is due to the fact that the active form of the transmembrane domain of the GABA B receptor is different from that of other GPCRs. The research work also provides details of the inter-subunit and intra-subunit changes, linking the agonist to activate binding to the G protein in the heterodimer complex. In conclusion, this study systematically identified the high-resolution cryo-EM structure of the C-type heterodimer GABAB receptor and G protein complex, and revealed a new mode of dimer GPCR coupling to G protein.

[9] On April 20, 2021, Zhejiang University Zhu Yongqun and Zhang Xing jointly published a research paper titled " Structural basis of assembly and torque transmission of the bacterial flagellar motor " in Cell . The atomic resolution cryo-electron microscope (cryo-EM) structure of the bacterial flagellar motor. The molecule is composed of 175 subunits and has a molecular weight of approximately 6.3 MDa. This structure reveals that the 10 peptides protruding from the MS ring with FlgB and FliE subunits mediate torque transmission from the MS ring to the rod and overcome the symmetry mismatch between the motor rotation structure and the helical structure. The LP ring contacts the distal rod and applies electrostatic force to support its rotation and torque transmission to the hook. This work provides detailed molecular knowledge for the structure, assembly and torque transmission mechanism of flagellar motors.

[10] On April 2, 2021, Xiao Fengshou, Meng Xiangju, Wang Liang of Zhejiang University and Zheng Anmin of the Institute of Precision Measurement Science and Technology Innovation of the Chinese Academy of Sciences published a joint communication titled " Isolated boron in zeolite for oxidative dehydrogenation of propane " on Science Online "The research paper uses the porous silicate zeolite (MFI) framework to separate boron, which prevents the complete hydrolysis and leaching of boron, thereby greatly improving the durability of the catalyst . Based on this strategy, the researchers designed a new active center with a –B [OH…O(H)–Si]2 structure in the MFI framework , which contains only isolated boron species , which not only effectively activates molecular oxygen and Propane promotes its dehydrogenation and prevents the complete hydrolysis of boron in the catalytic process. The research results show that the boron species separated from the MFI framework exhibits extremely high reactivity and selectivity to ODHP, and can achieve a conversion rate of up to 44% for propane, and the selectivity for ethylene exceeds 80% . The prepared BS-1 catalyst has water resistance and can maintain high activity and selectivity in continuous testing (210 h), thereby prolonging its service life. This means that ODHP technology has taken a big step forward in the future. It is expected to realize industrial application.

[11] On March 24, 2021, the team of Xu Huaqiang and Jiang Yi from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and the team of researcher Zhang Yan from Zhejiang University, jointly published the latest research results " Structural insights into the lipid and ligand regulation " in Nature . of serotonin receptors ", this work has successfully achieved multiple technological breakthroughs in this field, successfully resolved the five structures of three different types of serotonin receptors, and answered the above three scientific questions. This work reveals how phospholipid PI4P (PtdIns4P) and cholesterol regulate receptor functions, and how the drug Aripiprazole recognizes serotonin receptors. Aripiprazole is a first-line drug used clinically to treat schizophrenia, and it is also used to treat depression, bipolar disorder, autism and other important mental diseases.

[12] On March 3, 2021, Li Tiefeng's team from Zhejiang University published a research paper entitled " Self-powered soft robot in the Mariana Trench " in Nature . The research developed a wireless self -powered software that can be used for deep-sea exploration. The robots, through actual tests at the deepest point of 10,900 meters in the Mariana Trench and the deepest point of 3224 meters in the South China Sea, have verified that this robot has excellent pressure resistance and swimming performance. The research will contribute to the development of various other applied technologies, and further provide more innovative solutions for the promotion of marine monitoring, clean-up and prevention of marine pollution, and protection of marine biodiversity. More importantly, they can help scientists explore the depths of the ocean. Of unknown territory.

[13] On February 10, 2021, Xu Huaqiang's group from Shanghai Institute of Materia Medica, Chinese Academy of Sciences, combined with Zhang Cheng's group from University of Pittsburgh, Zhejiang University School of Medicine and Zhang Yan's group from Zhejiang Liangzhu Laboratory, and University of North Carolina Church The research group of Bryan L. Roth of Shan Branch published a research paper titled " Structural insights into the human D1 and D2 dopamine receptor signaling complexes " online in Cell . The research analyzed selective D1R agonists and non-selective dopamine receptor agonists The structure of D1R-Gs and D2R-Gi complex under activation, combined with functional test data, explained important biological issues such as the mechanism of D1R and D2R in ligand selectivity and G protein selective recognition. For the development of D1R and D2R provides an important structure and theoretical basis for targeted selective drugs and safer anti-neuropsychiatric drugs.

[14] On January 29, 2021, Zhejiang University, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Technical University of Denmark and other organizations cooperated. Wang Yong, Gao Yi, Jakob B. Wagner, Thomas W. Hansen and other joint communications were published on Science Online The research paper titled " In situ manipulation of the active Au-TiO2 interface with atomic precision during CO oxidation ", this research is the first to observe the reversible changes in the active sites of the catalyst interface during the process of catalytic oxidation of carbon monoxide at the atomic scale. Realize the atomic level in-situ regulation of active sites on the interface. This achievement is of great significance to the design of better environmental catalysts and the efficient and stable treatment of pollutant gases in the future.

[15] On January 6, 2021, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Peking University, Shandong University, Zhejiang University and other institutions cooperated. Xu Huaqiang, Zhang Yan and Sun Jinpeng jointly published a joint communication titled " Structures of the glucocorticoid " in Nature . -bound adhesion receptor GPR97–Go complex " research paper, which reports that glucocorticoid stress hormone activates the adhesion G protein-coupled receptor G3 (ADGRG3; also known as GPR97), a typical adhesion GPCR . The cryo-electron microscopic structure of the GPR97-Go complex bound to the anti-inflammatory drug beclomethasone or the steroid hormone cortisol showed that the glucocorticoid was bound to the capsular bag of the transmembrane domain. The steroidal core of glucocorticoids is stacked with the "toggle switch" residue W6.53, which senses ligand binding and induces receptor activation. Active GPR97 uses a quaternary core and HLY motif to immobilize the seven transmembrane bundles and mediate G protein coupling. There is an open cavity on the cytoplasmic side of GPR97, and all three intracellular loops interact with the Go protein, thereby promoting the high basic activity of GRP97. It has been found that palmitoylation of the cytoplasmic tail of the Go protein is essential for effective binding to GPR97, but it has not been observed in other complex structures of GPCRs that have been resolved. This research work provides a structural basis for the binding of the ligand to the seven transmembrane domains of the adhesion GPCR and the subsequent coupling of the G protein.

[16] January 6, 2021, in Shenzhen, a large Institute of Life Sciences, Kunming Institute of Zoology, University of Copenhagen and Zhangguo Jie, Zhou Qi, Zhejiang University and the University of Adelaide Frank Grutzner Corporate Communication in Nature published an article entitled "Online Platypus and echidna genomes reveal mammalian biology and evolution " research paper, this research published the genomes of platypus and short-nosed echidna (hereinafter referred to as echidna), and used their information to analyze the evolution of mammals and the evolution of monopore sex chromosomes , Provides new results for in-depth understanding of the important evolutionary process of mammals.

[17] Stimulus-responsive fusion and fission have been widely observed in biological tissues and artificial molecular assemblies. However, the design of a system with structural and characteristic persistence in the process of repeated fusion and fission is still challenging. On May 7, 2021, Zhejiang University's Gaochao team published a research paper titled " Reversible fusion and fission of graphene oxide–based fibers " in Science Online . The research first discovered graphene oxide (GO) fibers prepared by wet spinning. Under the trigger of the solvent, dynamic and reversible fusion and fission behavior will occur. At the same time, the concept is further extended to conventional fibers through GO coating, providing a general strategy for the design of functional response materials in the future.

大师大楼 · 发表于 2021-8-24 17:40:53

标志性论文越来越重要啦

大师大楼 · 发表于 2021-8-24 17:41:38

来源于 https://inf.news/en/science/f9b57095d6b4c83ba89c909536fa7156.html

胖妞 · 发表于 2021-8-25 09:01:23

有人说好像是18篇

academic818 · 发表于 2021-8-25 09:45:28

胖妞发表于 2021-8-25 09:01
0 X4 K$ }2 i3 p& D' x' k; ]有人说好像是18篇

还有一篇应该是共同一作环资学院方雪坤: https://www.nature.com/articles/s41586-021-03277-w (20210210,共同一作)

flyfish12345 · 发表于 2021-9-4 23:06:00

高质量研究越来越多

linslin · 发表于 2021-9-5 12:18:49

高质量研究越来越多。高校第一集团军，先发优势已经形成。

吉大数据统计 · 发表于 2021-9-5 22:59:32

整理的不够精简~

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Zhejiang University broke out，2021年已经在SNC 发表17篇论文（转...

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